Ceprano (Central-Northern Latian dialect: Ceprane) is a comune in the province of Frosinone, in the Valle Latina, part of the Lazio region of Central Italy.

In 1994, the Ceprano Man, a 450,000 year old prehistoric human skull cap, was discovered in the area.

Ceprano's origins are connected to a Roman colony founded in 328 BC on the left bank of the Liri River, called Fregellae.

Ceprano was part of the Papal States, from roughly the 6th century until 1870.

On 28 May 1944 Ceprano was liberated by Canadian troops as part of the Allies' push against German occupation.