[1] After minor participation in the Argentine Civil Wars since 1822, he was possibly part of the forces that, under the command of José Félix Aldao, fought in the Battle of Oncativo, and traveled to the Buenos Aires Provinces.

In 1840 he campaigned inland, in the ranks of Manuel Oribe's army, and fought in the battles of Quebracho Herrado, Sancala, Rodeo del Medio, and Arroyo Grande.

[2] Upon Justo José de Urquiza's invasion of Uruguay and the surrender of the besieging troops, many senior Argentine officers withdrew to Buenos Aires except for Domínguez.

A few days later, three officers who should have been incorporated into the Ejército Grande of Urquiza, Domínguez, Julián Martínez and Domingo Sosa, fled to Buenos Aires and presented themselves to Juan Manuel de Rosas.

In 1854, Governor Adolfo Alsina ordered for his arrest, accusing him of supporting the invasion of General Jerónimo Costa but Domínguez managed to flee to the Entre Ríos Province.

On June 10 of that year he was taken prisoner by the revolution led by Simón Luengo and sentenced to death at the instigation of Calixto González in the absence of Chacho Peñaloza.

He marched to the frontlines and under the orders of Emilio Mitre, he had an outstanding performance in the battles of Paso de Patria, Itapirú, Estero Bellaco, Tuyutí, Yataytí Corá, Boquerón and Curupaytí.