Independence Park features an equestrian monument to General José de San Martín, liberator of Argentina, Chile and Peru.

San Luis Airport is located less than 3.2 km (2 miles) north of the city centre, and has regular flights to Buenos Aires.

By the end of the 19th century, San Luis had 7,000 inhabitants, and in 1882 the Argentine Great Western Railway reached the city on its way to Chile.

San Luis lies at the foot of the Sierras Grandes, along the northern bank of the Chorrillos River, and is set on a dry pampas plateau, around 730 m (2,400 ft) above sea level.

Summers are hot and humid, and winters are cool and dry, with temperatures falling below 0 °C (32.0 °F) sometimes and snowfalls can occur occasionally.