His senior year, Carrillo posted a 9–1 record with an ERA of 0.96 while batting .370 with 5 home runs and 48 RBI which led to his selection to the All-State team.

Carrillo chose to attend the University of Miami to play baseball for head coach Jim Morris.

However, under NCAA regulations, a low score on the ACT exam which Carrillo took to gain entry into the university forced him to sit out the entire 2003 season.

However, Carrillo lost his last two decisions as a starter, the final one coming against Nebraska and Joba Chamberlain in the 2005 Super Regional.

Carrillo still compiled impressive stats in the 2005 season by going 13–3 with one save and a 2.22 ERA while striking out 127 batters in 125.2 innings pitched.

Carrillo began his professional career with the Single-A Lake Elsinore Storm where he started 7 games and went 1–2 with a 7.01 ERA with 29 strikeouts in 25.2 innings pitched.

Carrillo was sent to the Padre team specialist in San Diego and was told that he would need to rehab the elbow for roughly a month.

However, in early 2007, Carrillo's arm had not responded to rest and it was determined he needed Tommy John surgery on his elbow.

Carrillo made his Major league debut on August 13, 2009, against the Milwaukee Brewers, giving up three home runs.

On March 15, he was suspended for 100 games for violating the Minor League Drug Prevention and Treatment Program.

[11] The Tigers released him after the conclusion of his suspension[12] and he signed with the independent Sugar Land Skeeters of the Atlantic League of Professional Baseball.