Hunter Renfroe was born and raised in Crystal Springs, Mississippi, to parents Todd and Tammy.

[1] The Boston Red Sox selected Renfroe in the 31st round of the 2010 Major League Baseball (MLB) draft, but he did not sign.

[3] He was also named to the Golden Spikes Award watchlist[4] and was the 2013 recipient of the C Spire Ferriss Trophy, given to the best college baseball player in Mississippi.

[8] Renfroe agreed to a $2.678 million signing bonus[9] and began his professional career with the Eugene Emeralds of the Class A-Short Season Northwest League.

[11] Renfroe began the 2014 season with the Lake Elsinore Storm of the Class A-Advanced California League.

[15] Renfroe began the 2015 season with San Antonio and received a promotion in August to the El Paso Chihuahuas of the Class AAA Pacific Coast League.

[21] Following the 2016 Triple-A Baseball National Championship Game, the Padres promoted Renfroe to the major leagues on September 21.

[22] He made his first plate appearance as a pinch hitter that same night, getting intentionally walked by Arizona Diamondbacks reliever Edwin Escobar.

[25] On August 19, Renfroe was optioned to El Paso due to his declining performance in reaching base.

On December 6, 2019, Renfroe, Xavier Edwards, and a player to be named later (PTBNL) were traded to the Tampa Bay Rays in exchange for Tommy Pham and Jake Cronenworth.

[36] He also played in 11 postseason games, batting 7-for-36 (.194) as the Red Sox advanced to the American League Championship Series.

[36] On December 1, 2021, the Red Sox traded Renfroe to the Milwaukee Brewers in exchange for Jackie Bradley Jr., David Hamilton, and Alex Binelas.

[45][46] He was later added back to the IL on August 25 due to a right hamstring strain, before getting activated on September 5 for the team's playoff push.