Cesare da Sesto (1477–1523) was an Italian painter of the Renaissance active in Milan and elsewhere in Italy.
He is considered one of the Leonardeschi or artists influenced by Leonardo da Vinci, such as Bernardino Luini and Marco d'Oggiono.
In 1515 he finished a monumental polyptych for the Abbey of Santissima Trinità at Cava de' Tirreni and produced Leda and the Swan, a copy after Leonardo's own work on the subject.
Back in Milan, he executed a Baptism of Christ, in collaboration with Bernardino Bernazzano (now lost) and a Salomè, acquired by Rudolf II and now at the Kunsthistorisches Museum of Vienna.
He returned to Milan in 1520, where he painted the Madonna in Glory with Saints polyptych for the church of San Rocco (now in the Castello Sforzesco).