[1] Villella is co-founder of the filmmaking collectives Chad, Matt & Rob and Radio Silence.

[2] Among their numerous short films is the viral found footage style video Roommate Alien Prank Gone Bad and five installments of their first-of-its-kind series of Interactive Adventures.

After the dissolution of Chad, Matt & Rob, Villella formed Radio Silence with Bettinelli-Olpin, Tyler Gillett and Justin Martinez.

[12][13][14][15] On October 30, 2017, it was announced that the trio would adapt Bryce Moore's novel The Memory Thief for 20th Century Fox.

[16] In March 2020, it was announced that Villella would executive produce the fifth installment of the Scream franchise, alongside Kevin Williamson with Bettinelli-Olpin and Gillett co-directing.