Chaetomium thermophilum

[1] Since fungi are eukaryotic and not distant from animals they are good models for comparative and easy-to-manipulate research, and in the case of C. thermophilum, it is of special significance.

First, given the fact it is thermophilic, proteins derived from this fungus are heat stable and thus easier to work with.

Proteins from C. thermophilum are thermophilic and thus better for studies (structural and biochemical) than comparable mesophilic fungi.

The proteome of C. thermophilum has been studied and 27 distinct protein communities, including 108 interconnected complexes have been identified.

[4] The first observation of a metabolon in fatty acid metabolism at high resolution came from cryo-electron microscopic analysis of cellular homogenates from C. thermophilum.

Cryo-electron microscopic image of fractionated lysate from C. thermophilum cellular extracts. Megadalton protein complexes are observed (e.g. the barrel-shaped fatty acid synthase) that are either co-eluting or interacting to form higher-order protein complex assemblies (communities).