Chalk Bluff was an unincorporated community in Clay County, Arkansas, United States, approximately two miles (3 km) northwest of St. Francis.

The town was formed in the 1820s at the point where the St. Francis River cuts through Crowley's Ridge from west to east.

The founder of the community was Abraham Seitz, who established and operated a ferry crossing and general store in the area from the 1830 until it was destroyed during the Civil War.

The community occupied a strategic location and was often referred to in the reports of Union and Confederate forces vying for control of Northeast Arkansas during the war.

Several skirmishes occurred near the ferry crossing, one of which was significant it enough to become known as the Battle of Chalk Bluff, which took place in early May 1863.