It comprises 40 legislators, elected in a single province-wide multi-member district through proportional representation using the D'Hondt system.

[2] The establishment of the first legislature of Santiago del Estero was brought about by the adoption of the province's first constitution, in July 1956, during the governorship of Manuel Taboada.

[3] In 2002, following a declaration of a state of "political instability" by governor and caudillo Carlos Juárez, elections were rescheduled to take place a year earlier than anticipated.

[4] Since 2014, the Chamber of Deputies has convened in a new building built with the exclusive purpose of housing both meetings of the body and legislative offices of its members.

It is located on the corner of Avenida Roca and Patagonia, in the provincial capital, near the city's central bus station and not far from the governor's offices.