Its name is in honor of Henry H. Chambers,[2] who served as a United States Senator from Alabama.

[3] Prior to contact with people of European descent, what is now Chambers County was inhabited by the Creek nation.

Pat Garrett, the lawman famed for killing outlaw Billy the Kid, was born near the town of Cusseta in 1850.

Joe Louis "The Brown Bomber", renowned heavyweight boxing champion, was born near LaFayette, on Buckalew Mountain, May 13, 1914.

In 1980, Chambers County joined its four mill villages to make the city of Valley.

As of the 2010 census, there were 34,215 people, 13,933 households, and 9,391 families living in the county.

As of the 2000 census, there were 36,583 people, 14,522 households, and 10,194 families living in the county.

[16] School districts include:[17] Chambers is a Republican-leaning county, although it has a sufficient Black minority to return a respectable Democratic vote.

The last Democrat to win a majority in the county was Jimmy Carter in 1980, although Bill Clinton won pluralities in it in both 1992 and 1996.

Chambers County has been the backdrop of several movies including Mississippi Burning.