During transcription, viral polymerase synthesizes five discrete mRNAs and obeys to stop signals present at the gene boundaries.

[5] Geographically, Chandipura virus human infections so far have been described only in central India; however WHO suspects it could be found in other Asian or African countries,[5] as CHPV has been isolated from wild sandflies in Africa.

[5] Symptoms of Chandipura virus infection typically include fever, muscle aches and headache.

[7] The complicated course with brain infection includes convulsions, and unconsciousness, progressing rapidly to coma and in severe cases to death.

CNS imaging showed brain edema due to middle cerebral artery infarction or vasospasm,[7] with endothelial damage being the result of encephalitis.

[7] Diagnosis of Chandipura virus infection is confirmed with immunoglobulin M enzyme-linked immunosorbent assay (IgM ELISA) or reverse transcription polymerase chain reaction (RT-PCR).

[10] No specific treatment or vaccine is available for Chandipura virus infection, so management focuses on supportive care and prevention measures such as mosquito control.

[8] Between June and August 2003, 329 children contracted the virus, and 183 died in Andhra Pradesh and Maharashtra states of India.

[14][15] Sandfly bites were blamed for the outbreak, as they inhabit cracks in walls or parts of homes made of sand or mud.

The outbreak raised public health concerns due to the rapid spread and the severity of symptoms observed.