It is one of the constituent colleges of Shaheed Mohtarma Benazir Bhutto Medical University (SMBBMU).

[3] The school has a large and experienced faculty to support its mission of education, research, and clinical care.

There are approximately 100+ full-time faculty members consisting of demonstrators, assistant, associate, and full professors at CMC Larkana.

[5] Professor and surgeon Dr. Sikandar Ali Sheikh became its first vice chancellor on 9 July 2009.

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