The film revolves showcases the life of a curious medico Karthik who investigates the mystery surrounding a closed Karthikeya temple in the village of Subrahmanyapuram.

[2][3] An incident which happened in Talupulamma Temple in Kakinada district of Andhra Pradesh inspired Chandoo Mondeti to pen the story of Karthikeya.

He later directed the crime drama film Bloody Mary (2022) stars Nivetha Pethuraj, Brahmaji, Ajay, and Kireeti Damaraju.

[7] Filming took place in India, predominantly in Gujarat and Himachal Pradesh, in addition to Spain, Portugal, and Greece in Europe.

Karthikeya 2 was released in August 2022 and received positive reviews from critics and became the highest grossing film in Mondeti's career.