The film's six-song soundtrack and background score are composed by Vidyasagar with lyrics written by Vaali, Yugabharathi, Pa. Vijay, Na.

Chandramukhi is Vidyasagar's first and only collaboration with Rajinikanth, and also being the first time where the actor's film was scored by a different composer apart from Deva and A. R. Rahman in the past decade.

[7] The duet "Konjum Neram" was performed by Madhu Balakrishnan and Asha Bhosle, who was roped in after producer Ramkumar Ganesan suggested her name.

[10] The album was released at the film's music launch held on 5 March 2005 at the Taj Connemara hotel in Chennai.

[8] After several months, the producers issued an original soundtrack—which includes the background score and the dialogues from the film—were released on 27 September 2005 at the film's silver jubilee event, in the presence of Ramkumar, Prabhu, Vidyasagar and Vasu.

[12][13] The first time, a re-recording of the film score being unveiled into a separate album, it was accompanied with a video CD titled "The making of Chandramukhi".

[12] Released as a limited-edition collectable, the soundtrack was unveiled after tremendous pressure from the actor's fans and the proceedings from the CD sales will be donated to the Sivaji-Prabhu Charities Trust.

Vidyasagar is a gifted composer but has apparently felt cramped by the tailor-made songs that a Rajni film demands of him".