Channel Q's programming schedule consists of LGBT-centered talk shows, most notably a rebooted version of Loveline, along with Dance/Top 40 music on afternoons, late nights, and weekends.

[1] A full launch occurred on October 11, 2018, a date chosen to coincide with National Coming Out Day, and featured a daily morning program co-hosted by Queer Eye alum Jai Rodriguez; weekly shows featuring internet personality B. Scott and lawyer/politician John Duran; and a revamped version of the syndicated radio program Loveline.

[2] By November 1, the network would adopt the Channel Q name, tweak its program lineup, and add its first analog radio affiliate (KQPS in Palm Springs, California).

As of March 2020, Channel Q's program schedule features early morning, afternoon, and weekend blocks of Top 40, pop, EDM, and dance music along with regularly-scheduled shows.

Those shown with an "HD2" or "HD3" suffix air Channel Q on an HD radio subchannel that can be heard through HD-accommodating receivers.