Thuy is known for her portrayal of the DC Comics character Grace Choi on the CW Network show Black Lightning (2018), which ran for four seasons.
In 2018, Thuy optioned Caroline Vu's novel, That Summer in Provincetown, about three generations of Vietnamese Canadians and is currently looking to adapt it into a screenplay.
[3] In 2021, Thuy began portraying detective Lia Kaleo on the CBS action-crime drama series Magnum P.I..[4] In 2024 she won the Canadian Screen Award for Best Supporting Performance in a Drama Film at the 12th Canadian Screen Awards, for her performance in the film Ru.
[5] In February 2019, Thuy co-starred in Tracy Letts' play, Linda Vista, at the Mark Taper Forum in Los Angeles and later reprised her role on Broadway with the Second Stage Theater at the Helen Hayes Theatre.
She appeared as Marie Louise-Yvette L'Amour in the play "The Lady Was Gentleman" with the Broads' Word Ensemble in Los Angeles.