She made her professional acting debut when she was 12, playing an orphan in a summer stock production of Annie.

Booth's first starring role in a movie came with the 2003 heist film Foolproof opposite Ryan Reynolds.

In 2008 she made a breakthrough with two performances, as a desperate crack whore in This Beautiful City and a comic turn as part of an ensemble cast of Young People Fucking, for which she was given the Genie Award for best supporting actress.

Starting in 2014, she appears in the Hallmark original movie series Signed, Sealed, Delivered as Shane McInerney, a techie postal employee.

[2] In 2018, Booth was one of four actresses who filed lawsuits against Albert Schulz, for sexual harassment allegations related to their time working with him at Soulpepper Theatre.