She also starred in Denis Villeneuve's thriller Enemy (2013), the period drama Belle (2013), and the action horror film Dracula Untold (2014).

The next year, she starred in the period film Indignation, and co-starred in the supernatural thriller The 9th Life of Louis Drax, and as Sadie Dunhill in the Hulu miniseries 11.22.63, an adaptation of Stephen King's novel 11/22/63.

Gadon has received numerous accolades, including three Canadian Screen Awards for Alias Grace, Enemy, and The Great Darkened Days.

(1999), Young Laura Burnham in Twice in a Lifetime (2000), Catherine Hartman in Mutant X (2002), Claudia in Dark Oracle in 2004, Vicki in Life with Derek (2005), and Tasha Redford in Flashpoint (2008).

Other roles include Sarah in Phantom of the Megaplex (2000), Samantha in What Girls Learn (2001), Amanda in Cadet Kelly (2002), Julia Norton in Code Breakers (2005) and Celeste Mercier in The Cutting Edge: Chasing the Dream (2008).

Gadon had recurring roles in many television series: Zoe Kessler in The Border (2008–2009), Katie Atkins in Being Erica (2009), Georgia Bravin in Happy Town (2010) and Ruby Odgen in Murdoch Mysteries (2009–2011).

She is also behind the voice of the title character in the animated series Ruby Gloom (2006–2007), Beth in Total Drama (2007–2011) and Portia in Friends and Heroes (2007–2009).

Gadon was nominated for a Gemini Award in 2008 for Best Individual or Ensemble Performance in an Animated Program or Series for her work in Ruby Gloom (2008).

Burgeon and Fade won the Special Jury Award at the WorldFest Houston Festival for original dramatic short film.

[15] In 2011, Gadon starred in David Cronenberg's Cosmopolis, alongside Robert Pattinson, as his on-screen wife of 22 days, Elise Shifirin.

She co-starred in Denis Villeneuve's Enemy (2013), based on the José Saramago book, The Double (2002),[21] and in David Cronenberg's Maps to the Stars (2014), a dark comic look at Hollywood excess.

In September 2014, it was announced that she was cast in Miramax's supernatural thriller The 9th Life of Louis Drax, along with Jamie Dornan and Aaron Paul.