Charis Eng (17 January 1962 – 13 August 2024) was a Singaporean American physician-scientist and geneticist at the Cleveland Clinic, notable for identifying the PTEN gene.

[5] Afterwards, she completed her residency in internal medicine at Beth Israel Hospital, Boston and trained in a fellowship in medical oncology at Harvard's Dana-Farber Cancer Institute.

[2][8] Eng joined the Cleveland Clinic in 2005,[9] and became the founding director of the Cleveland Clinic's Genomic Medicine Institute and the Center for Personalized Genetic Healthcare (CPGH), and Professor and Vice Chair of the Department of Genetics and Genome Sciences at Case Western Reserve University School of Medicine.

[10][14][15] From her research, Eng led the development of clinical practice guidelines in cancer screening in patients with these mutations.

[16] Her scientific accomplishments have set the practice model for how to apply laboratory-based genetics and genomics in the pre-symptomatic diagnosis, counseling and management of patients and their as-yet unaffected family members.