[5] Through his multiple academic appointments, Wexner personally trains 15-20 surgeons each year, and he educates thousands more around the world through conferences and lectures.

[9] In 1988 he completed a fellowship in colon and rectal surgery at the University of Minnesota Medical School in Minneapolis, MN.

[12] he led a multi-faceted coalition to establish the accreditation program with the American College of Surgeon's Commission on Cancer.

The NAPRC's goal is to implement nationwide educational and medical standards for the best treatment of rectal cancer.

[4] In an interview with Local 10, Wexner shared that he has been seeing a higher frequency of colorectal cancer in younger patients, due to genetic drift as well as environmental and dietary factors.

[14] This is often misdiagnosed until the disease has become advanced, and so Wexner recommends beginning regular colonoscopy screenings earlier than guidelines currently advise.

Much of Wexner's work has been focused on improving surgical techniques for the avoidance of permanent stomas in patients with colorectal cancer, ulcerative colitis, and fecal incontinence.

He introduced a popular modification to the technique for creating an ileo-anal pouch, or j-pouch for ulcerative colitis, in which double stapling is used in place of sutures to improve results.

[16] The J-pouch, an alternative to a permanent ileostomy or colostomy, allows patients who have had their colons removed to continue to have regular bowel movements without an ostomy bag.

[7] The score measures the severity of constipation by taking into consideration a number of factors, which his research found to correlate with objective physiologic findings.

The factors include the frequency and completeness of bowel movements, the difficulty of evacuation, the type of assistance used (if any), the patient's level of pain, and duration of constipation.

The goal of the scoring system is to utilize a patient's medical history and the results of physical examination to predict the likelihood of success of surgical intervention.

[19] Prior to the development of this method, doctors lacked reliable indices of disease activity or prognostic implications from surgery.

In 2019, Wexner was awarded an Honorary Fellowship by the Royal College of Physicians and Surgeons of Glasgow, Scotland.

[21] From 2011 to 2012, Wexner served as president of the American Society of Colon and Rectal Surgeons,[22] for which he gave a Presidential Address in 2012.

[25] In 2007 he delivered the SAGES Presidential Address entitled "Trials and tribulations in the history of surgical innovation.

[33] On October 19, 2021, Elsevier published a list of the top cited scientists from 198 different fields and sub-fields based on the Scopus database.

AIS works with a constantly growing network of hospitals and key opinion leaders and validating academic and scientific societies.

Wexner has been involved in dozens of broadcasts with topics ranging from robotic colorectal surgery teaching techniques to discussing diversity, equity, and inclusion issues in healthcare.