[1] Charles attended the Collège du Havre[1][2] and possibly the Ecole publique des mathématiques et d'hydrographie.

From 1826 to 1837, Lesueur was based in New Harmony, Indiana, where he filled sketchbooks full of the finds discovered during the utopian adventure funded by his friend and former employer, American geologist William Maclure.

"[6] Indeed, Lesueur sent specimens of unique fish, animals, and fossils, as well as artifacts he had dug from the Indian Mounds in New Harmony, back to France, where they remain.

He had spent 21 years in the United States, but continued his scholarly studies and activities in France, where he resumed his occupation of artist-naturalist and began to catalogue his extensive research and artwork.

In the 1900s, his work was finally published by the museum, totaling over 60 books, including reports of his zoological, geological, historical, and archaeological research, as well as studies of his life.

The original hangs in the reading room of the Ewell Sale Stewart Library in the Academy of Natural Sciences of Philadelphia.