Charles-Michel Mesaiger (7 March 1689 – 7 August 1766) was a French Jesuit priest who spent some time in missionary work in present-day Canada.
Mesaiger arrived in Canada in 1722 and spent a number of years in the mission to the Ottawas at Michilimackinac.
He was instrumental in sending out the first party which built Fort St. Pierre on Rainy Lake in 1731.
He had influenced the beginning of the La Vérendrye explorations which would continue to push westward.
His replacement, Jean-Pierre Aulneau, was to become a martyr in carrying on the mission that Mesaiger had started.