A painter, printmaker, teacher, lecturer, historian, magazine and book illustrator, Wilson's work has been shown in over 200 exhibitions in the United States and across the globe.

Many of Wilson’s works hang in the Oklahoma State Capitol including life-size portraits of Will Rogers,[3][4] Sequoyah,[5] Jim Thorpe and Senator Robert Kerr.

These Pawnee and Seneca tribespeople were included in Benton's mural at the Harry S. Truman Presidential Library, Independence and the Opening of the West.

His works include prize-winning books such as the classic Treasure Island, Company of Adventurers, Henry's Lincoln, and Mustangs.

Commissioned by John D. Rockefeller Jr. in 1955, Wilson's mural "The Trapper's Bride" is among the most superb records of the American West's fur trade.

Wilson created the designs for "The First American Series", basalt medallions depicting famous Indian chiefs, which were produced by Josiah Wedgwood and Sons, Inc., England.

One major undertaking was creating the murals for the Oklahoma Capitol, which depict the state's discovery, frontier trade, Indian immigration, settlement, and overall history.