Driscoll was born south of Wichita, Kansas on a farm that was purchased by his father after emigrating from Ireland by way of New York and Ohio.
Kansas Irish was republished by Rowfant Press in 2011 in an illustrated paperback edition, introduction by Dr. Matthew Jockers.
He began his career as a journalist writing for the Wichita Eagle, and is popularly credited as the originator of the "school page" in newspapers.
Driscoll became editor of the Wichita Eagle in 1919 but was forced out of his position in the 1920s by the Ku Klux Klan, active in Kansas politics at the time.
Dr. Matthew Jockers has written on the importance of Driscoll as a writer on the Irish in the West ["A Window Facing West: Charles Driscoll's Kansas Irish" New Hibernia Review Volume 8, Number 3], helping to revive interest in his writing and life.