He was elder son of John Trye, rector of Leckhampton, near Cheltenham, by his wife Mary, daughter of the Rev.
John Sheldon engaged him to assist in his private anatomical school in Great Queen Street.
[1] Sheldon descended into mental illness and left London, and Trye returned to Gloucester, where he was appointed house apothecary to the infirmary on 27 January 1783; shortly after leaving this post he was elected in July 1784 surgeon to the charity, a position he filled until 1810.
[1] Trye died on 7 October 1811, and was buried in the churchyard at St Mary de Crypt Church, Gloucester.
A plain tablet, with an inscription prepared by Trye himself, was put up in the church at Leckhampton, while a public memorial to perpetuate his memory was placed in Gloucester Cathedral, a medallion-bust of Trye by Charles Rossi in the west end of the north aisle.