Charles Colcock Jones Sr. (December 20, 1804 – March 16, 1863) was an American Presbyterian clergyman, educator, and planter of Liberty County, Georgia.

His paternal grandfather was major John Jones Sr., who was killed in the siege of Savannah twenty-five years before Charles's birth.

He then moved to Philadelphia and served as corresponding secretary of the Board of Domestic Missions of the Presbyterian Church until 1853, when his health failed and he returned again to Liberty County.

Jones's Catechism of Scripture Doctrine and Practice (1837) was translated into Armenian and Chinese, and he also wrote History of the Church of God (1867).

His brother-in-law wrote that Jones "did more than any other man in arousing the whole church of this country to a new interest in the spiritual welfare of the Africans in our midst.