Charles-Dominique-Joseph Eisen (17 August 1720 – 4 January 1778) was a French painter and engraver.

The son and pupil of Frans Eisen, he was born at Valenciennes.

His talent and his sparkling wit gained him admission to the court, where he became painter and draftsman to the King, and drawing-master to Madame de Pompadour.

The most notable of these are the designs for the Fermiers généraux edition of the Contes of La Fontaine, published at Amsterdam in 1762; Ovid's Metamorphoses, 1767–71; the Henriade of Voltaire, 1770; the Baisers of Dorat, 1770; and the Vies des Peintres hollandais et flamands of Descamps, published in 1751–63.

There are pictures by him in the Museums of Bordeaux, Alençon, and Bourg, and even at Nordnorsk Kunstmuseum in Tromsø, Norway.