Charles Frederick II of Württemberg-Oels (7 February 1690 in Merseburg – 14 December 1761 in Oleśnica) was a Duke of Oels-Württemberg and Regent of the Duchy of Württemberg.

When his father died in 1704, Charles Frederick was still a minor, so he stood under guardianship until he was declared an adult in 1707.

In this rôle, he succeeded Duke Charles Rudolph of Württemberg-Neuenstadt, who had resigned from the regency for reasons of old age.

Georg Bernhard Bilfinger, Johann Eberhard Georgii and Frederick Augustus von Hardenberg served as ministers in his government.

In 1744, he resigned from the government in Oels, in favour of the son of his younger brother Charles Christian Erdmann.