Charles II (26 January 1555 – 17 May 1589) was Lord of Monaco from 7 October 1581 to 17 May 1589.

Charles was the eldest son of Honoré I, Lord of Monaco (1522–1581), and Isabella Grimaldi (died 1583).

Protected by Spain, due to the Treaties of 1524, Charles was the first lord of Monaco who refused to pay homage to the duke of Savoy for Mentone and Roccabruna.

Charles ruled for only 8 years before dying at the age of 33.

He left no issue and so his youngest brother, Hercule, became lord of Monaco.