Her father decided, with the permission of Louis XIV, that her future husband should assume the surname of Grimaldi and rule Monaco jointly with her.

On 20 October 1715, at the age of eighteen, she married Jacques François Goyon, Count de Matignon, after his family had proposed him as a candidate.

His candidacy was supported by King Louis XIV, who wanted to consolidate French influence in Monaco.

[1] Louise Hippolyte and Jacques, who was troubled by this state of affairs, left Monaco after their marriage to reside in France, dividing their time between the royal court of Versailles, Paris and their estate in Normandy.

The marriage was not happy; Louise Hippolyte was described as a shy and submissive personality, while Jacques openly flaunted his mistresses in the royal court at Versailles.

After the death of her father on 20 February 1731, Louise Hippolyte traveled without her family from Paris to Monaco and received an enthusiastic reception from the populace upon her arrival on 4 April 1731.

As was customary in the case of female monarchs, it had originally been the plan to proclaim Jacques as her joint co-regent.