Charles Knight is a British professor of cardiology and chief executive of St Bartholomew's Hospital, part of Barts Health NHS Trust.

In 1994 he assisted in the first percutaneous alcohol septal ablation, a non-surgical method for the treatment of hypertrophic obstructive cardiomyopathy as an alternative to open heart surgery, and subsequently specialised in the procedure.

[1][2] In 1994, at the Royal Brompton Hospital, he assisted Ulrich Sigwart with the introduction of percutaneous alcohol septal ablation, a non-surgical method for the treatment of hypertrophic obstructive cardiomyopathy, as an alternative to open heart surgery.

[8] In March 2020, Knight was appointed chief executive officer of NHS Nightingale Hospital London, established to care for people during the COVID-19 pandemic.

[1] He is a trustee of Barts Heritage,[14] Fellow of the Royal College of Physicians,[1] and is an honorary professor at the William Harvey Research Institute at Queen Mary University of London.