[4] Charles Wesley (1707–1788),[3] and his wife, Sarah Gwynne (1726–1822) from Brecknockshire, moved into the house in September 1749, after their marriage earlier that year.

By 1756 this lifestyle had taken its toll on his health, and after that year he made no further long journeys to distant parts of the country.

[5] He was the Methodist "minister in residence" for Bristol,[5] and was described in the St James's Church parish records as a "preacher at the Horsefair".

The boys' earliest musical influence was their mother, who had a good singing voice and played the harpsichord.

From around the age of six, Charles junior had lessons from Edmund Rooke, who was organist at All Saints' Church from 1759 and at Bristol Cathedral during 1769–73.

[7] The two attached houses at 4 and 5 Charles Street have been designated by English Heritage as a Grade II* listed building.