About this time, he painted a notable incident from the colonial era, The Abduction of Boone's Daughter by the Indians (1855–1856).

A recent exhibit at the Amon Carter Museum described the painting as showing five Indians and Jemima in a canoe, each wondering when rescuers would come for her.

[2] Wimar primarily painted the themes of Indian life on the Great Plains, showing the Native American hunts of buffalo and other activities related to their nomadic lives.

He also painted scenes of the emigrant wagon trains that carried pioneer settlers across the western expanses.

He made two long trips in 1858 and 1859 up the Missouri River, and was inspired by his experiences and observations of Native American life.