[1] Giving historically focused largely on the global Jewish community, Israel, and the family's hometown of Tulsa, Oklahoma, but later expanded to support equity and inclusion efforts in the U.S.[2][3] After Charles' death in 2000, Lynn Schusterman continued to lead the organization, joined by her daughter, Stacy H. Schusterman.

[4] Charles and Lynn Schusterman Family Philanthropies distributes over $400 million annually to a variety of causes in the United States and Israel.

[10] The Schustermans launched the Black Principals Network in 2021, which later folded into the Surge Institute to support leadership opportunities for people of color in education.

[16] The Schusterman family are major donors for social service initiatives in Israel, with specific focus in supporting at-risk women and victims of child abuse.

In 2022, they supported the construction of a field hospital following the Russian invasion of Ukraine with the Israel Foreign Affairs Ministry.

[21] They are contributors to Repair the World, a Jewish service organization,[22] BBYO, Hillel International,[23] Moishe House.