[4] She attended Swarthmore College, where she participated in many extracurricular activities such as ice hockey, student government, glee club, and tutoring.

Miller, Moore obtained a job at the Princeton University Observatory working for Professor Henry Norris Russell as a human computer carrying out calculations needed to use photographic plates in determining the position of the Moon.

[4] While working for Russel, Moore initially felt nervous about her inexperience, but over time her interest in astrophysics began to blossom.

Moore said “I was used to prejudice against women because Princeton was a man's stronghold, and a woman was really out of step there.”[8] Though in 1926, Russell left his own name off a paper they worked on together and used hers alone.

[8] After five years at Princeton, Moore took a leave of absence due to ill health and she moved to the Mount Wilson Observatory as part of an ongoing collaboration between Russell and research groups there.

[9] Her tables of atomic spectra and energy levels, published by NBS, have remained essential references in spectroscopy for decades.

"[8] In 1949 she became the first woman elected as an associate of the Royal Astronomical Society of Great Britain, in honor of her work on multiplet tablets and in identifying solar spot electra.

Throughout her career she authored and co-authored over 100 papers and attended the tenth general assembly of the International Astronomical Union on the Joint Commission on Spectroscopy in Moscow in 1958.