[3] Like many Southern lines, the Cheraw and Darlington Railroad suffered during the American Civil War.

In the waning days of the conflict, a considerable portion of the carrier's infrastructure was ordered destroyed by invading Union forces.

Maj. Gen. William T. Sherman sent a mounted infantry force to Florence, South Carolina, to level the depots, trestle-work, bridges, and public buildings and stores.

[4] In the course of the action, which took place in March 1865, 500 yards (460 m) of trestle work, two depots, 11 freight and four passenger cars were destroyed, along with a considerable amount of supplies.

The line is still in service from Florence to Floyds and is now operated by the South Carolina Central Railroad.