The Cheraw and Salisburg Railroad was a shortline railroad that ran between Cheraw, South Carolina, and Wadesboro, North Carolina.
[1] At the company's 1869 annual meeting stockholders approved changing the name of the carrier to Cheraw and Salisbury.
[1] The carrier was originally charged with building a line between Cheraw and Salisbury, North Carolina, a distance of approximately 80 miles (130 km).
The line began operation in 1868 and by the early 1870s, according to the 1873 American Railroad Manual for the United States and the Dominion, track had been laid between Cheraw and Wadesboro, a distance of 23 miles (37 km).
After several more mergers and consolidations, it is now part of CSX Transportation.