The Cherohala Skyway is a 43-mile (69 km) National Scenic Byway and National Forest Scenic Byway that connects Tellico Plains, Tennessee, to Robbinsville, North Carolina, in the southeastern United States.

Along with multiple vistas and overlooks, the skyway provides easy vehicular access to various protected and recreational areas of the Unicoi Mountains, including the Citico Creek Wilderness, the Bald River Gorge Wilderness, and the remote interior of the Joyce Kilmer Memorial Forest.

Planning for the Cherohala Skyway began in 1958 and the road was completed on October 12, 1996, at a final cost of about $100,000,000.

The western (or Tennessee) half of the skyway follows Tennessee State Route 165 for nearly 25 miles (40 km) from Tellico Plains to the state line at Stratton Gap.

The North Carolina half of the skyway terminates near the south shore of Lake Santeetlah.