The turnpike carries US-412 for its entire length; the old alignment of US-412, which was also at one time State Highway 33, is now US-412 Alternate.

[1] An Oklahoma Tourism Information Center is located on the turnpike near the Kansas exit, 13 miles (21 km) from the Arkansas–Oklahoma state line.

[1] Tolls are collected for eastbound traffic upon exiting at Locust Grove and Leach, and entry at Kansas.

Westbound traffic must pay toll upon exit at Kansas and entry at Leach and Locust Grove.

[2] On May 20, 2021, Senator Jim Inhofe, Republican of Oklahoma, introduced legislation to designate the portion of US-412 between I-35 in Noble County and I-49 in Springdale, Arkansas as future Interstate 42.

The senators' stated reasons for seeking an Interstate designation along the US-412 included encouraging economic development, expanding opportunities for employment in the region, making travel safer and shipping easier, attracting new businesses, and better connecting rural and urban communities.

Other supporters of the measure include the mayor of Tulsa, G. T. Bynum, and the heads of both ODOT and the Arkansas Department of Transportation (ArDOT).