The Indian Nation Turnpike is built to parkway-like design standards, omitting a center barrier and left-hand shoulders for a slightly mounded grassy median that is flush with the edge of the left lane in each direction.

The route is one continuous four-lane limited access highway, but consists of two separately constructed sections.

On August 2, 2021, the Oklahoma Transportation Commission unanimously approved a motion to apply the SH-375 designation to the turnpike.

ODOT Director Tim Gatz stated in the Transportation Commission meeting that the numbering addition was primarily to aid in navigation using digital mapping and routing applications.

A two-axle vehicle pays $14.55 ($6.35 with Pikepass and other compatible systems) to drive the full length of the turnpike.