Cherry Pie Sison Picache (born May 27, 1970) is a Filipino actress.

In 2006, S Magazine named her one of Philippine cinema's best actresses of all time.

She attended Saint Mary's College of Quezon City, St. Paul University Quezon City, and took up dentistry at Centro Escolar University.

Picache made her television debut in the soap opera Familia Zaragoza aired on ABS-CBN in 1996, and received more projects from that network.

[2] In September 2014, Picache's mother, Zenaida was found dead after several stab wounds.