[3] Referred to as the "Divine Diva",[4] Padilla is recognized as one of the top female recording artists in the Philippines.

She's best known for ZsaZsa Zaturnnah Ze Moveeh, Batang PX, Ako Legal Wife: Mano Po 4 and Minsan Lang Kitang Iibigin.

Padilla and her husband, architect Conrad Onglao dwell on a $6.8 million U-shaped mansion upon a 1,386 square-meter lot in Barangay San Lorenzo Village.

The couple also owns Casa Esperanza, their green holiday cottage in Lucban, Quezon.

[13] Padilla suffers from a birth defect, megaureter since her left ureter caused her chronic urinary tract infection.