The Chesepian or Chesapeake were a Native American tribe who lived near present-day South Hampton Roads in the U.S. state of Virginia.

[1] Two other Chesepian towns were Apasus and Chesepioc, both near the Chesapeake Bay in what is now the independent city of Virginia Beach.

Archaeologists and others have found numerous Native American arrowheads, stone axes, pottery, and beads in Great Neck Point.

The Chesepian were eliminated because Powhatan's priests had warned him that "from the Chesapeake Bay a nation should arise, which should dissolve and give end to his empire".

[2][3] Though historians of the period express little doubt that the Powhatans eradicated the Chesapeake tribe, Strachey's belief that these rumored prophesies indicated the Christian God's intervention on behalf of the Jamestown Colony against "The Devil's Empire" appears, in hindsight, rather eccentric.