The Wicocomico /waɪkɛ'kɑːməkɛ/ were an Algonquian-speaking tribe who lived in Northumberland County, Virginia, at the head and slightly north of the Little Wicomico River.

Due to constant encroachment and manipulation by settlers, opportunists, and Captain Smith, as well as internal conflict regarding how to respond to these, the tribe splintered.

The English colonists assigned them a flag and a reservation of 4,400 acres (18 km2) near Dividing Creek, south of the Great Wicomico River.

Wicocomico is also written Wiccocomoco, Wighcocomoco, Wicomico, Wicomoco (by James Mooney), Wicocomoco (by John Reed Swanton), and Wicacoan.

Sometime between 1652 and 1655, the Court directed the Wicocomico and Chicacoan (or Sekakawons) tribes to merge and relocate slightly south of the Great Wicomico River.

The court appointed Machywap (formerly the leader of the Chicacoan) as the weroance of the combined tribes, as he had an English wife, was therefore considered a friend of the Smith and his fellow colonists and "easy to manage (manipulate)".