Chesnee is a city in Spartanburg and Cherokee counties, in the U.S. state of South Carolina.

Cleveland named the company - and later the town - after his great-grandmother, Margaret Chesnee, who was born in Scotland.

[6] The Clinchfield Railroad ran an excursion train over the newly laid rails to Spartanburg on October 23, 1909.

U.S. Route 221 passes through the city as Alabama Avenue and Hampton Street, leading north 18 miles (29 km) to Rutherfordton, North Carolina, and south 16 miles (26 km) to Spartanburg.

South Carolina Highway 11 (Cherokee Street) crosses US 221 in the center of town and leads west 19 miles (31 km) to Campobello and east past Cowpens National Battlefield 14 miles (23 km) to Gaffney.

According to the United States Census Bureau, Chesnee has a total area of 1.14 square miles (2.94 km2), all land.

[5] As of the 2020 United States census, there were 829 people, 324 households, and 159 families residing in the city.