Smyrna is a small town in York and Cherokee counties in the U.S. state of South Carolina.

The population was 45 at the 2010 United States Census,..[5] The Jackson's Furnace Site (38YK217) was listed on the National Register of Historic Places in 1987.

According to the United States Census Bureau, the town has a total area of 0.69 square miles (1.8 km2), all land.

There were 29 housing units at an average density of 43.3 per square mile.

31.8% of all households were made up of individuals, and 31.8% had someone living alone who was 65 years of age or older.

18.2% of all households were made up of individuals, and 4.5% had someone living alone who was 65 years of age or older.

Incorporated in 1895, the town of Smyrna took its name from the Smyrna Associate Reformed Presbyterian Church that had been providing a place of worship to the local residents for fifty years.