It is managed by the Chesterfield Royal Hospital NHS Foundation Trust.

The hospital has its origins in a dispensary established in a small house in St. Mary's Gate in 1854.

[1][2] The foundation stone for a new purpose-built facility was laid by the Marquis of Hartington on the site of Durrant Hall in 1859.

[3] It was officially opened by the Queen in 1985 and was extended to include a maternity and gynaecology unit in 1989.

[5] People born at the hospital include Thomas Raymond Latimer, a professional wrestler currently based in the United States where he performs under the ring name Bram.