[1] He was drafted by the Philadelphia Eagles, but he served in World War II for the United States Navy.

[2][3] After going back to Xavier to graduate in 1946, he was acquired by the Buffalo Bisons of the newly formed All-America Football Conference.

Mutryn led the AAFC in the touchdown category while being named First-team All-Pro.

In the fourth quarter, trailing 17–14, Mutryn had apparently caught a pass from George Ratterman before fumbling the ball, which the Colts had recovered.

His total yard count in rushes, receptions, and returns (1,330) led the league for the second time.

Buffalo finished fourth in the seven-team AAFC, but it was good enough to qualify for the semifinal playoff against the top team in Cleveland.

Mutryn caught two passes for touchdowns that kept Buffalo in check (they led as late as the third quarter 21–17).

[8] Upon Buffalo being shut out of the league, Mutryn went to the Baltimore Colts upon their absorption into the NFL in 1950.