He played college football at USC and was selected by the Philadelphia Eagles in the first round of the 2015 NFL draft.

[3] As a true freshman in 2012, Agholor played in all 13 games as a backup wide receiver and recorded 19 receptions for 340 yards and two touchdowns.

[11] On December 13, He scored his first NFL career touchdown, a 53-yard reception from quarterback Sam Bradford, in a matchup against the Buffalo Bills.

On September 10, 2017, in the season opening 30–17 victory over the Redskins, Agholor had a 58-yard receiving touchdown from quarterback Carson Wentz in the first quarter.

[19] In the 2018 season opener, against the Atlanta Falcons, Agholor completed his first career NFL pass attempt to Nick Foles on a trick play that went for 15 yards.

[20] In the next game, he scored his first receiving touchdown of the 2018 season as part of an eight-reception, 88-yard performance against the Tampa Bay Buccaneers.

[21] He put his best statistical performance of the season in the Week 16 32–30 victory over the Houston Texans with five receptions for 116 yards and a touchdown.

However, with his team down late in the fourth quarter, he dropped a wide-open pass that could have led to the go-ahead score after losing it in the lights of Mercedes-Benz Stadium.

[28] Agholor entered training camp competing for a starting wide receiver job against Tyrell Williams, Zay Jones, Hunter Renfrow, and rookies Henry Ruggs and Bryan Edwards.

At the end of training camp, head coach Jon Gruden named Agholor the fourth wide receiver on the Raiders' depth chart, behind Ruggs, Edwards, and Renfrow.

In Week 5 against the Chiefs, Agholor caught two passes for 67 yards, including a 59-yard touchdown reception, as the Raiders won 40–32.

[32] In Week 16 against the Miami Dolphins, Agholor recorded five catches for 155 yards, including an 85-yard touchdown reception, during the 26–25 loss.

[39] He finished the season sixth on the team with 31 catches for 362 yards and two touchdowns, his lowest mark since his rookie year.